Arshad Chowdhury has a post making the rounds wherein he talks about the things he has learned and gained from standing at work all day long for two years. I have not noticed either of the side effects he mentioned (both the positive and negative), but most of what he says I am in agreement with.
I started standing occasionally on October 10th, 2010 and went full-time on January 25th, 2011. What I can tell you about standing is that it has done wonders for me. It has alleviated a lot of back pain, and leg numbness that I had. My feet don’t get tired standing and truly don’t seem to ever get tired anymore.
I can also tell you that sitting down feels really fucking great. I don’t know if any of the health benefits are true, but my guess is that a mix of standing and sitting is the best for people. Since I don’t care to stand while I drive, or while I watch TV at home, I stand while I work.
I do advise against the setup as Chowdhury has pictured, and seems to recommend. If that’s his setup in the picture, I’d run away from that (which is easier because I am already standing). The problem with his setup is that he is looking down too much, and that will always be an issue if you use a laptop as your entire setup (meaning as your monitor, mouse, and keyboard).
I use my laptop for the screen, but have a keyboard and trackpad separate from it. This type of arrangement allows me to raise up the laptop screen to a height more inline with ergonomic guides on the issue.
If you are standing for health reasons, you should probably make sure you get all the benefits by adjusting your screen height. Even if you don’t stand, it’s a good idea to get that screen a little higher than you are probably used to.